Prerequisites and compatibility



The Zebra input and output can be created, processed and studied entirely on-line via the web-interface. The only software required on the user side is an HTML5-compatible web-browser. In addition, you may wish to download the output data to your computer and study them off-line. For this you may need the PyMol molecular graphics engine.

All steps of the Zebra+Mustguseal web-server protocol are executed entirely on the server side. You do not need any specific software on your side. The Zebra's output is primarily web-based and viewable on the site. The Analysis section of the Results page offers interactive content for analysis of the produced results. Interactivity is implemented in HTML5 and therefore neither plugins nor Java are required. The only prerequisite for viewing the Analysis section of the Results page is an HTML5-compatible web-browser. Current versions of all major browsers support HTML5 as the default standard.

Zebra2 is compatible with all major operating systems and browsers. The recommended browser is Google Chrome due to a better visual appearance.

The Zebra web-server was checked for compatibility with the following Operating Systems (OS) and web-browsers (see below). Table legend: "Submit" - can be used to submit a new task to Zebra; "Download" - can be used to download the results for the off-line analysis using the download links at the Results page; "On-line" - can be used to view and operate the results at four information levels using interactive HTML5-based tools: as a sequence similarity network (SSN), interfaces to 3D-structure-based (3D) and sequence-based (Seq) analysis of conservation and variability, and accompanied by the detailed annotation of proteins accumulated from the integrated databases with links to the external resources (DB); "Delete" - can be used to delete user data from the server using the Delete button (see more about task retraction at this page).

OS Browser Submit Download On-line Delete
SSN 3D Seq DB
Linux openSuSE 15.0 Google Chrome 79.0.3945.88 Yes Yes Yes Yes Yes Yes Yes
Mozilla Firefox 68.2 Yes Yes Yes Yes Yes Yes Yes
Opera 63.0.3368.66 Yes Yes Yes Yes Yes Yes Yes
MS Windows 8.1 Google Chrome 79.0.3945.88 Yes Yes Yes Yes Yes Yes Yes
Mozilla Firefox 71.0 Yes Yes Yes Yes Yes Yes Yes
Opera 65.0.3467.78 Yes Yes Yes Yes Yes Yes Yes
MS Windows 7 Google Chrome 77.0.3865.90 Yes Yes Yes Yes Yes Yes Yes
Mozilla Firefox 71.0 Yes Yes Yes Yes Yes Yes Yes
Opera 65.0.3467.78 Yes Yes Yes Yes Yes Yes Yes
MacOS Mojave 10.14.6 Safary 13.0.3 Yes Yes Yes Yes Yes Yes Yes
iOS 13.2.3 (iPhone Xs) Safary (iPhone Xs) Limit* Limit* Yes* Yes* Yes* Yes* Yes*

* iPhones have a limited functionality when it comes to storing, uploading, and downloading files. An iPhone can be easily used to create a new Zebra2 task via the Mustguseal in the Mode 1 (provide a PDB code of the query protein to the Mustguseal to create the alignment, and then submit this alignment to Zebra2 in one click, i.e., no file transfer from your device is required), and then study the output on-line using the HTML5 interactive tools. The Mustguseal/Zebra2 were not optimized for iPhones; however, the modern large-screen devices are capable of automatically fitting the web-server pages into their viewports. Technically, you may be able to download the output files via iPhone and store them to an external cloud service - please consult your cloud service documentation.


Compatibility notes. Zebra2 is compatible with all major operating systems and browsers. Minor compatibility issues were detected when running the SSN viewer on old browsers. If you are experiencing technical problems when using the Zebra2 on-line analysis toolkit (including the SSN viewer), please follow this guideline:

  • Upgrade to the latest version of your current web-browser;
  • If the problem still persists, try using a different browser already installed on your system. Try upgrading to the latest version of that browser;
  • If the problem still persists, download and install the latest version of the Google Chrome;

If this guide did not solve your problem, please send us a message explaining the details.

The PyMol molecular graphics engine will be required to operate the Zebra annotation file on a local computer. PyMol can be installed from a Linux repository (e.g., in openSuSE you should try the "zypper in pymol" command), compiled from sources (recommended for advanced users only) or purchased from the distributor Schrödinger LLC (external link). Alternatively, the results of the Zebra2 can be operated on-line using the built-in interactive analysis tools. Interactivity is implemented in HTML5 and therefore no plugins nor Java are required.