The visualCMAT: a web-server to select and interpret
correlated mutations/co-evolving residues in protein families


Version 1.0

Choose input mode

Submit a new task
Claim your results by TaskID (access the results and progress log of a previously submitted task)
Submit a multiple protein alignment and a representative protein structure as a new task, or access a previous submission by TaskID

Submit a new task


The multiple protein alignment

Upload a file with a multiple protein alignment in fasta format. File size must not exceed 50 MB. File extention must be "fasta" or "fasta_aln". E.g.: filename.fasta_aln. No alignment? Use the Mustguseal web-server to construct one automatically.
The representative protein structure

Upload a file with protein structure in the PDB format. File size must not exceed 10 MB. File extention must be "pdb". E.g.: filename.pdb.
Enter a chain ID (e.g., 'A' to select chain A or 'first' to select the first chain in the uploaded file)
Enter a positive integer (e.g., '10' to select the 10-th protein in the alignment to match the protein structure, or 'auto' to select the best match automatically)
Structural filtration of correlated pairs
Enter a floating-point number (e.g., '5' to set the cut-off to 5 angstroms)
Select the MI-based score measure of residue correlation
The MIc / Zc statistics
The MIp / Zp statistics
Select the Mutial Information-based score measure of residue correlation
Security and sharing
No Yes

No Yes

CMAT options
Enter an integer between 1 and 9999 (e.g., 500)
Henikoff`s position-based weights
No sequence weight
Select the CMAT sequence weight method
Profile-based pseudocount
Simple pseudocount
No pseudocount
Select the CMAT pseudocount method
Enter a floating-point number (e.g., 0.05)
Enter a floating-point number (e.g., 0.5)
Enter a floating-point number (e.g., 1.0)
Profile-based adjusment
No adjustment
Select the CMAT joint probability adjustment method
Enter a floating-point number (e.g., 0)
Enter a floating-point number (e.g., 3.5)
Enter a floating-point number (e.g., 3.5)
Enter a floating-point (e.g., 0)
Enter an integer number (e.g., 4)